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Research Study: A single inhalation of 5-MeO-DMT is related to positive mental health shifts

A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms

Interesting Segments

“A recent survey among users of 5-MeO-DMT (toad, synthetic, or plant derived) indicated that most respondents used 5-MeO-DMT for spiritual exploration and reported mystical-type experiences of moderate-to-high intensity (Davis et al. 2018). Interestingly, those respondents who reported a psychiatric disorder mentioned that 5-MeO-DMT had helped them reduce their symptoms of anxiety, depression, and post-traumatic stress, or effectively deal with alcoholism and drug abuse.”

“Some reports suggest that the secretion of the Bufo alvarius toad may have been used historically by indigenous peoples in the southwestern territory of the USA and northern Mexico (Weil and Davis 1994).”

“A single inhalation of vapor from dried toad secretion containing 5-MeO-DMT produces sub-acute and long-term changes in affect and cognition in volunteers. These results warrant exploratory research into therapeutic applications of 5-MeO-DMT.”

Abstract

Background: 5-methoxy-N,N-dimethyltryptamine (hereinafter referred to as 5-MeO-DMT) is a psychedelic substance found in the secretion from the parotoid glands of the Bufo alvarius toad. Inhalation of vapor from toad secretion containing 5-MeO-DMT has become popular in naturalistic settings as a treatment of mental health problems or as a means for spiritual exploration. However, knowledge of the effects of 5-MeO-DMT in humans is limited.

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