Exploring the Research on 5-MeO-DMT
At Enfold, we are committed to staying informed on the latest scientific research regarding 5-MeO-DMT and its therapeutic benefits.
The growing body of research on 5-MeO-DMT highlights its profound potential for addressing PTSD, depression, anxiety, and addiction, with promising safety and neurobiological benefits. Below, we highlight key studies that provide insight into its effects on mental health, neurogenesis, safety, and therapeutic applications.
5-MeO-DMT for PTSD
A Real-World Longitudinal Case Study
- This study presents the first longitudinal case on 5-MeO-DMT for chronic, refractory PTSD in a 23-year-old female.
- A single dose of vaporized bufotoxin (containing 10–15 mg of 5-MeO-DMT) led to significant improvements in PTSD symptoms, including reduced hopelessness and suicide risk.
- The participant reported a complete mystical experience, which may contribute to 5-MeO-DMT’s therapeutic effects.
- Benefits were sustained at 1, 3, 6, and 12 months.
Depression and Anxiety
Fast-Acting Psychedelic Effects
- A survey of 362 adults found that approximately 80% reported reduced anxiety and depression after 5-MeO-DMT use.
- Positive outcomes correlated with mystical experiences and increased personal meaning.
Treatment-Resistant Depression
Phase 1/2 Trial of Vaporized 5-MeO-DMT (GH001)
- A study of 16 patients with treatment-resistant depression found that individualized dosing (up to three doses in one day) provided ultra-rapid antidepressant effects.
Safety and Tolerability
Short-Term Safety Profile in Clinical Trials
- A systematic review found that 5-MeO-DMT has a favorable short-term safety profile.
- No serious adverse events (SAEs) were documented, and no participants withdrew due to side effects.
Neurogenesis and Cellular Benefits
A Single Dose Stimulates Brain Growth and Immunomodulation
- Research indicates that 5-MeO-DMT promotes neurogenesis, enhances neuron survivability, and supports the immune system.
Biological and Psychological Effects
Effects on Inflammation, Cortisol, and Well-Being
- A study examining vaporized synthetic 5-MeO-DMT found reductions in inflammatory markers, improved mood, and increased non-judgmental awareness.
Alcohol Use Disorder
Study of Intranasal 5-MeO-DMT
- A single dose led to significant and sustained reductions in alcohol consumption.
- 50% of patients maintained complete abstinence over three months, with heavy drinking days reduced from 56% to 13%.
Comparing 5-MeO-DMT to Other Psychedelics
Narrative Review of Research
- Findings suggest that 5-MeO-DMT has a risk profile similar to psilocybin, with high rates of ego-dissolution and mystical experiences.
- These effects correlate with long-term therapeutic benefits, supporting further clinical exploration.
More Research on 5-MeO-DMT
Enfold x UHN Research Study
Enfold has partnered with UHN, Canada’s largest research hospital, to produce observational research looking at 5-MeO-DMT in a retreat-based setting. The research will include both a qualitative and quantitative components.
University Health Network (UHN) is a research hospital affiliated with the University of Toronto and a member of the Toronto Academic Health Science Network. The scope of research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care.
This research will be the first time a solid set of data is collected with before and after measures along with precise dosing and set & setting parameters collected.